Protective effects of thymoquinone against hexavalent chromium-ınduced nephrotoxicity: a multiparametric evaluation of oxidative stress, ınflammation, ferroptosis- and apoptosis-related markers
Jul 2026· Molecular and Cellular Biochemistry· Vol 481, pp. 4043 - 4061· 0 citations· 96 references
Medicine
TL;DR
Tq attenuates Cr(VI)-induced nephrotoxicity, as evidenced by improvements in oxidative stress, inflammation, DNA damage, ferroptosis- and apoptosis-related markers, together with preservation of renal structure and function.
In the kidney tissue of rats in the PD group, elevated levels of MDA, NF-κB, and TNF-α were noted relative to other experimental groups, although activities of GSH, SOD, and CAT were decreased and histopathological changes in kidney tissue were assessed.
Tansu Kuşat, Feyza Başak, Eyüp Altınöz et al.· Medical Journal of Western B...· 0 citations
Both plant extracts exert significant hepato- and nephroprotective effects against cisplatin-induced toxicity, likely through antioxidant and cytoprotective mechanisms, and support their potential use as complementary agents to mitigate chemotherapy-induced organ toxicity and prevent weight loss.
Danielle Yaba Ambassa, Charnelle Fokoua Bakam, B. E. Enang et al.· Exon· 0 citations
This study provides the first demonstration that asiatic acid exerts robust systemic antioxidative, hepatoprotective, and neuroprotective effects against CPF-induced toxicity, highlighting AA’s therapeutic potential for mitigating organophosphate pesticide poisoning.
Özge Darakcı Saltık, H. Balcı, Figen Güzelgül et al.· Yüksek İhtisas Üniversitesi...· 0 citations
Compared to crude CRV, CRV-PNPs provided significantly better protection against Pb-induced hepatotoxicity by restoring hematological indices and liver function, correcting dyslipidemia, and attenuating histopathological alterations.
Eman E. Elwakeel, Ahmed Abdeen, A. Elzeer et al.· Tissue & Cell· 0 citations
The protective mechanism involves anti-oxidant enhancement and inhibition of oxidative stress-induced inflammation and apoptosis, supporting the therapeutic potential of HSP in managing phthalate-related renal injury.
Tuba Karaarslan, B. Yıldırım, F. Yildirim et al.· Iranian Journal of Basic Med...· 0 citations
Rosmarinus officinalis extract may exert protective effects against MTX-induced hepatorenal injury through antioxidant and anti-inflammatory mechanisms, however, further studies are required to confirm these effects and validate their therapeutic potential.
Lana Muhammed, Nadia Salih· Open Veterinary Journal· 0 citations
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