Aug 2026· Neurochemical Research· Vol 51· 0 citations· 49 references
Medicine
TL;DR
It is suggested that IMD-1 attenuates H2O2-induced oxidative injury in SH-SY5Y cells as evidenced by changes in oxidative stress, mitochondrial dysfunction, ATP-associated bioenergetic impairment, inflammatory mediator release, and apoptosis-related responses.
Oxidative stress and disruption of intracellular Ca2+ homeostasis contributes to dopaminergic neuronal damage in Parkinson’s disease. In this study, the protective effects of Ginkgolide B (GKB) against 6-hydroxydopamine (6-OHDA)-induced SH-SY5Y cell damage were investigated, with particular attention to oxidant-evoked...
Ramazan Çınar, Merve Göztepe, Adem Ahlatcı et al.· Current Issues in Molecular...· 0 citations
It is demonstrated that BSA-MnO2 NPs protect PC12 cells against H2O2-induced oxidative injury by restoring autophagy through the PI3K/Akt signaling pathway, highlighting a potential role of BSA-MnO2 NPs in the treatment of oxidative-stress-related neurodegenerative disorders.
Wei-Jian Zeng, Duan-Yang Zhou, Tian-Long Wang et al.· Pharmaceutics· 0 citations
Neurodegenerative diseases represent a significant clinical challenge. Understanding the pathogenic mechanisms is essential for developing more effective therapies, and mitochondria appear to play a key role in these processes. Since current treatments are limited to symptom management, natural strategies capable of pr...
Martina Farina, G. T. Patanè, Stefano Putaggio et al.· Biomolecules· 0 citations
The findings support a ROS-dependent mitochondrial apoptotic response under elevated in vitro GEN exposure but do not establish selective antitumor cytotoxicity or direct physiological relevance.
Samak Sutjarit, C. Sakulthaew, Nattakan Meekhanon et al.· Journal of Xenobiotics· 0 citations
Glutamate-induced excitotoxicity, characterized by oxidative stress and genomic instability, is a hallmark of neurodegenerative disorders. This study investigated the protective effects of curcumin against glutamate-induced excitotoxicity in SH-SY5Y cells, focusing on oxidative balance and DNA integrity. SH-SY5Y cells...
B. Tan, Seza Nur Suluhan, Oğuzhan Yaylalı et al.· Drug and chemical toxicology...· 0 citations
It is suggested that melatonin protects BEAS‐2B cells against H/R‐induced injury, and that this protective effect may be associated with reduced oxidative stress, preservation of mitochondrial function, and suppression of necroptosis‐related signaling.
Zehra Yılmaz, Askin Tas, Ozlem Oz et al.· Cell Biochemistry and Functi...· 0 citations
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