TL;DR
It is demonstrated that APS may attenuate CDDP-induced oxidative stress and iron overload, thereby inhibiting ferroptosis and alleviating lung cell injury and may provide a potential clinical application.
ASIV pretreatment attenuated UVA-induced injury in HaCaT keratinocytes, reflected by improved antioxidant status, preserved MMP, and reduced apoptosis, and may warrant further investigation as a protective compound against skin photodamage.
Abstract Objectives Acute lung injury (ALI) is driven by oxidative stress and disrupted redox homeostasis. While curcumin is a potent natural antioxidant, its clinical application is limited. We evaluated the protective capacity and underlying mechanisms of sAc15, a stable curcumin analog, in ALI models. Methods In vi...
AlCl₃ exposure led to increased MDA levels and decreased GSH levels, with reduced SOD and CAT activities in heart tissue, which led to increased MDA levels and decreased GSH levels, with reduced SOD and CAT activities in heart tissue.
ABSTRACT Cisplatin, a commonly used chemotherapy drug, inevitably causes damage to the liver and kidneys while exerting its anti‐tumor effects. Carboxymethylated Poria cocos polysaccharides (CMP) have anti‐inflammatory, antioxidant, and organ‐protective properties, and also exhibit significant anti‐tumor activity. Ther...
Cisplatin-induced nephrotoxicity remains a major limitation in chemotherapy, primarily mediated through oxidative stress and apoptosis in renal cells. The present study evaluated the nephroprotective potential of a hydroalcoholic polyherbal extract comprising Ajuga bracteosa and Gynura procumbens (1:1) against cisplati...
ABSTRACT Cisplatin (CDDP) is a widely used chemotherapeutic agent, but its nephrotoxic side effects limit its clinical application, which can lead to severe acute kidney injury (AKI). Growing evidence indicates that ferroptosis plays a critical role in CDDP‐AKI. Rosmarinic acid (RA) is a natural polyphenolic compound e...
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