Open access
Genomics of multidrug-resistant Klebsiella pneumoniae isolates from community hospitals in Pretoria, South Africa
Mokawane Victor Mohlamoyane
J. Pitout
T. Lentswe
Sarah Liknaitzky
K. T. Salvador-Oke
A. Moultrie
Mishalan Moodley
Jonathan Featherston
Anthony M. Smith
Arshad Ismail
Mohamed Said
M. Ehlers
Marleen M. Kock
Medicine
Abstract
Highlights • The sequence type 307 clone is highly prevalent in South African hospitals.• Pandrug ST307 high-risk clone with three carbapenemases is a public health threat.• Emerging double-carbapenemase producers reduce available treatment options.• Diverse plasmids drive antibiotic resistance in Klebsiella pneumoniae, enabling spread.• No convergence of multidrug resistance and hypervirulence.