Open access
Safety of Coadministration of Continuous Infusions of Propofol and Clevidipine: A Multi‐Site Retrospective Analysis
Micaela N. Warfield
Kristin C. Cole
K. Heybati
Nicholas J. Vollmer
Erin D. Wieruszewski
Hemang Yadav
Alejandro A. Rabinstein
Caitlin S. Brown
Medicine
Abstract
Patients often receive propofol for sedation and clevidipine for hypertension in the intensive care unit. Both agents are formulated as a lipid emulsion, which may increase the risk of hypertriglyceridemia and acute pancreatitis with their coadministration. We aimed to determine the incidence of hypertriglyceridemia and acute pancreatitis with concurrent administration of propofol and clevidipine and identify patient risk factors for hypertriglyceridemia.