FORMULATION AND OPTIMIZATION OF SOLID LIPID NANOPARTICLES (SLNs) OF BUDESONIDE

Abstract

The present study was aimed at the formulation and optimization of Budesonide-loaded Solid Lipid Nanoparticles (SLNs) to improve the solubility, bioavailability, and sustained-release characteristics of Budesonide, a BCS Class II corticosteroid drug. SLNs were prepared using the hot homogenization technique employing Glyceryl Behenate and Glyceryl Monostearate as lipid matrices and Soya Lecithin as the surfactant. Various formulations were prepared by varying lipid-to-surfactant ratios (2:1, 2.5:1, 3.3:1, 5:1 and 10:1). The prepared formulations were evaluated for drug content, entrapment efficiency, particle size, zeta potential, in vitro drug release, and stability studies. Among all formulations, F3 containing a lipid-to-surfactant ratio of 3.3:1 showed optimum characteristics with nanosized particles, high entrapment efficiency, satisfactory zeta potential and sustained drug release up to 12 h. The optimized formulation demonstrated the suitability of SLNs as an effective carrier system for enhancing the therapeutic performance of Budesonide.