Skip to content
Log in
Sponsored Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt Design Multi-Agent AI Systems Using MCP and A2A: Engineer your own Pyt

Bovine AAV - a promising vector for pulmonary gene therapy

Daniela C. Ivan Valérie Dubost L. Israel J. Weinmann Dennis Ungan Nina Carbonetti N. Stuber Magali Jivkov Esther Erard E. Biglieri Federica De Girardi Simon Mittermeier Maryam Syed B. Tigani Najwa Ouali-Alami Kristin Dreessen Colin Deniston Kannan Sankar Laura Bollepalli Vanessa Cornacchione E. Traggiai Dominique Brees A. Karle J. Carballido A. Cirillo
Jul 2026 · bioRxiv · 0 citations
Biology

TL;DR

Bovine AAV is position as a promising lung-tropic and immune-distinct vector for pulmonary gene therapy, with particular relevance for applications requiring systemic delivery in the presence of pre-existing immunity to conventional serotypes.

DOI Semantic Scholar
View source

Similar papers

Open access Jul 2026

A novel adeno-associated viral vector derived from human spleen isolate AAV.hu.S17

This study generated a novel recombinant AAV vector rAAV.hu.hu.S17, derived from the human spleen isolate AAV.hu.S17, and systematically evaluated its capsid features, in vitro transduction, and in vivo tissue tropism.

Wenyan Guo, Jiawen Sun, Fei Wang et al. · 0 citations
Open access Jul 2026

AAV Vector Toolkit for the Delivery and Expression of the Artificial microRNA in the Murine Heart

It is shown that systemic AAV administration provides potent delivery and uniform transduction of cardiac tissue, outperforming localized injection techniques and establishing an effective AAV approach for transgene transfer into the mouse heart and promote the development of gene therapy for cardiac disorders.

I. Galkin, V. Skopenkova, Maria Y. Shubina et al. · 0 citations
Open access Aug 2026

Functional evaluation of a natural AAV capsid liver targeting motif in human hepatocytes

The results showed the potential of a combinatorial AAV library for model validation and revealed the human microliver platform-PEG as a reliable system for the development of AAV therapeutics.

Carmen Unzu, Amanda X. Chen, Liliana Mancio-Silva et al. · 0 citations
Aug 2026

Durational Study of Persistent Transduction of Rhesus Macaque Lung and Other Organs Following Single Dosing with AAV1-CFTR

The findings indicate sustained gene transfer and transduction for at least 180 days following a single AAV1 administration to the primate lung, with minimal immunopathology, which supports the potential feasibility of extended dosing intervals and informs the development of repeatable AAV-based gene therapies for CF.

Prajita Paul, Tanvi Sharma, M. Afshani et al. · 0 citations
Open access Aug 2026

AAVR disruption as a producer-cell engineering strategy for enhanced supernatant-based recovery of selected AAV serotypes

In supernatant AAV vector recovery assays, AAVR knockout increased supernatant vector genome recovery for selected serotypes in a representative clone, although this effect varied among independently isolated clones.

Kenji Sakamoto, Kouhei Yoshida, Yuji Tsunekawa et al. · 0 citations
Open access Sep 2026

MADCAP: isolation of novel nAb-naïve AAV capsids from metagenomic data

This work establishes metagenomic mining as a powerful tool for accelerating AAV capsid discovery, identifying isolates with favorable tissue tropisms and resistance to broadly neutralizing antibodies.

E. Lyashenko, Tess Torregrosa, Alexandra B. Ysasi et al. · 0 citations

We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.