Dynamic-Bonded Conductive Pressure-Sensitive Adhesive Elastomer for Antibacterial Wound Repair and Real-Time Strain Monitoring.

Abstract

Effective monitoring of mechanical stimuli such as pressure and torsion is essential for guiding wound management, yet current pressure-sensitive adhesives rarely integrate stable sensing, tissue-compatible adhesion, and antibacterial protection. Here, we develop a multifunctional conductive pressure-sensitive adhesive elastomer (PTAHCA) constructed from a dynamic thioctic-acid-based polymer network reinforced with clay nanotubes and ionic components. Synergistic dynamic covalent and non-covalent interactions stabilize the polymer matrix and markedly enhance its mechanical robustness and functional durability. PTAHCA exhibits high electrical conductivity, tissue-compatible adhesion, rapid self-healing, and broad-spectrum antibacterial activity while maintaining excellent biocompatibility. Its pronounced strain-dependent electrical response enables real-time detection of subtle skin deformation for continuous motion and physiological activity monitoring. In vivo studies further show that PTAHCA efficiently eliminates wound-associated bacteria, promotes collagen deposition, and accelerates tissue regeneration. This integrated material strategy establishes a versatile platform for next-generation intelligent wound dressings that combine sensing, protection, and therapeutic functions. This material strategy provides a versatile adhesive elastomer platform that supports both antibacterial wound repair and real-time strain monitoring, offering a promising route toward next-generation multifunctional wound dressings.