TL;DR
Remifentanil attenuated LPS-induced hepatic injury, and this effect was found to be associated with modulation of oxidative stress responses, inflammatory alterations, and necroptosis-related gene expression.
Taxifolin conferred a substantial renoprotective effect against acute kidney impairment induced by sepsis by reducing inflammatory responses, oxidative stress, and preserving tubular structural integrity.
In this exploratory model, remogliflozin was associated with attenuation of TAA-induced renal injury and modulation of related biomarkers, and warrants further preclinical investigation in TAA-associated renal injury.
Overall, RSG pretreatment protects against LPS‐evoked ALI partially through enhancing PPARγ activity and inhibiting the cellular stress response in the mouse lungs.
MA attenuates sepsis-associated ALI through anti-inflammatory, antioxidant and anti-apoptotic effects and this mechanism is related to inhibiting the activation of the PI3K/AKT/mTOR signaling pathway.
Collectively, DAPA exhibits hepatoprotective and neuroprotective effects against TAA-induced HE accompanied by modulation in oxidative-, inflammatory-, and apoptotic-related protein expression, highlighting its therapeutic potential in hepatic encephalopathy.
Treatment with high-dose BBP significantly ameliorated lung pathologies in the mouse models and improved the aberrant alterations in pulmonary expressions of inflammatory factors, oxidative stress-related indicators and the NF-κB and Nrf-2/HO-1 pathways.
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