Aug 2026· Archives of pharmacal research· Vol 49, pp. 1032 - 1052· 0 citations· 140 references
Medicine
TL;DR
Evidence linking dysregulated cGAS–STING activation to inflammatory remodeling, senescence-associated changes, cell injury, fibrosis, and tissue dysfunction is synthesized, while highlighting the context-dependent roles of this pathway across physiological aging and ARDs.
The mechanisms of cGAS-STING activation in aging-including mitochondrial DNA leakage, nuclear envelope disruption, and retrotransposon activation-and its role in driving cellular senescence and the senescence-associated secretory phenotype (SASP) are reviewed.
Yutong Wei, Sutong Cai, Ya-Nan Ji et al.· Biochemical Pharmacology· 4 citations
This review systematically elucidates the molecular basis of the mtDNA-cGAS-STING pathway, delves into its organ-specific activation mechanisms, and critically evaluates current intervention frameworks and clinical prospects, aiming to provide a theoretical basis and innovative perspectives for the precision prevention...
Ling Wang, Zheng-Wei Zhang, Bin-Bin Xia et al.· Frontiers in Immunology· 0 citations
How context determines the consequences of cGAS/STING activation in cancer is examined, emerging therapeutic strategies that modulate this pathway are reviewed, and how its antitumor potential can be maximized while minimizing systemic toxicity and immune dysregulation is discussed.
Yi Wang, J. Angulo-Lozano, Yue-Qi Wang et al.· Journal of Clinical Investig...· 0 citations
This review synthesizes current research on how intracellular C3 (intC3), and intracellular C5 (intC5) in certain contexts engage in extensive crosstalk with the mTOR, NF-κB, and AMPK pathways to modulate core cellular processes to modulate age-related diseases.
Naheemat Modupeola Gold, M. N. Okeke, Samuel Ewhea Ajoronor et al.· Ageing Research Reviews· 0 citations
A novel perspective on the inflammatory mechanisms underlying diabetes mellitus and its complications is provided, thereby establishing a theoretical foundation for the development of therapeutic strategies centered on modulating the cGAS-STING pathway.
Guang-Dong Qi, Tong-Xin Shang, Hua-Lin Sun et al.· Frontiers in Pharmacology· 0 citations
How the delicate balance between acute and chronic STING signaling in the setting of underlying genetic regulation and immune landscape can play critical role in determining clinical outcome is discussed.
Satyaki Bhowmik, Subhadeep Ghosh, A. Sengupta· Experimental Hematology· 0 citations
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