2026· Advances in Immunology· Vol 171, pp.
307-341
· 0 citations
Medicine
TL;DR
This work situates MiET formation within the broader microglial functional repertoire and focuses on how ET-dominant responses may compromise homeostatic or neuroprotective roles, expanding the conceptual framework for microglial pathogenicity and inviting future mechanistic and translational research.
Advanced fluid biomarkers, such as seed amplification assays (SAA), alongside multidimensional neuroimaging techniques (PET, SPECT, MRI), are proving crucial for detecting these early microglial and pathological changes to guide personalized, disease-modifying therapies of PD.
Manuel Debasa-Mouce, Alberto Ouro, J. De Leon et al.· Advances in Immunology· 0 citations
The protective and deleterious roles of NETs are investigated and how this knowledge may reveal new therapeutic strategies to modulate neurodegenerative diseases and preserve neural integrity are investigated, offering valuable insights for potential applications in clinical practice.
Alzheimer's disease (AD) is a progressively debilitating neurodegenerative condition characterized by the accumulation of amyloid-β (Aβ), tau pathology, synaptopathy, and neuron loss. Recent studies suggest that Neuroinflammation is a critical part of the disease process rather than an accompanying feature of the menti...
Almas Meheboob Pathan· International Journal of The...· 0 citations
Overall, pyroptosis provides a novel framework for understanding the interplay between neuroinflammation and neurodegeneration in AD; however, its cell-type-specific roles, stage-dependent effects, and translational potential remain to be fully elucidated.
Xin-Kai Wu, Qiuyan Ye, Ming-Sheng Zi et al.· Molecular and cellular neuro...· 0 citations
This review summarizes recent advances in microglial biology across acute brain injury, neurodegenerative and demyelinating disorders, central nervous system infections, and psychiatric and neurodevelopmental diseases and provides new opportunities for precision therapy.
Jie Chen, Wangzheqi Zhang, Li-Zhou Song et al.· Clinical and Translational M...· 0 citations
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