Historical-Feature Residual Adaptation for Sequential Screening
Yixiang HongYuchen Zhang
Oct 2026
Machine Learning
Abstract
Sequential screening policies must use acquired feedback effectively under a fixed experiment budget. We study acquisition-time residual adaptation: a small ranking correction built from fixed historical features and anchored to base scores recorded before feedback is revealed. The interface accepts a history-conditioned scorer and a candidate feature table; its primary instantiation augments AssayFormer's ten-dimensional representation with 64 historical directions while retaining the pretrained model. In retrospective evaluation on 20 official-test screens from 15 recorded sources, a comparison fixed before target-outcome access increased source-macro fraction of hits recovered from 22.58% to 28.61%, exceeding all six prespecified comparators. A same-feature ordinary ranking head achieved 25.73%. Supplementary strong logistic, rank-fusion, and unprojected controls achieved 26.42%, 26.02%, and 26.78%, respectively. A separate model-independent pilot on 13 reused development screens reconstructs the features without AssayFormer assets. Across three seeds, residual adaptation improves random-forest hit recovery from 28.87% to 31.27%, while logistic recovery changes from 30.22% to 29.78%. The results show effective pretrained-policy adaptation and useful transfer to an independent nonlinear base, with gains that depend on the base model.
This paper investigates developing real-world perception for active agents, proposes Gibson Environment for this purpose, and showcases a set of perceptual tasks learned therein.
F. Xia, Amir Zamir, Zhi-Yang He et al.· 2018 IEEE/CVF Conference on...· 1,069 citations· ⚡112
The results indicate that software engineering work practices are chosen opportunistically, adapted and configured to provide value under the constrains imposed by the startup context.
Nicolò Paternoster, Carmine Giardino, M. Unterkalmsteiner et al.· Information and Software Tec...· 394 citations· ⚡54
The possibility of inferring high-dimensional data inference in a model that consists of a prior and an auxiliary differentiable constraint given some additional information is considered, thereby allowing a range of potential applications in adapting models to new domains and tasks.
Alexandros Graikos, Esmeralda S. Whitammer, N. Jojic et al.· Neural Information Processin...· 316 citations· ⚡15
It is proved that any global minimizer of the trajectory balance objective can define a policy that samples exactly from the target distribution, and empirically demonstrate the benefits of the trajectories balance objective for GFlowNet convergence, diversity of generated samples, and robustness to long action sequenc...
Esmeralda S. Whitammer, Moksh Jain, Emmanuel Bengio et al.· Neural Information Processin...· 302 citations· ⚡60
An algorithm is proposed which leverages disentangled semantic factors to generate adversarial perturbation by altering controlled semantic attributes to fool the learner towards various "adversarial" targets.
Haonan Qiu, Chaowei Xiao, Lei Yang et al.· arXiv.org· 208 citations· ⚡17
This work proposes a HALO that directly maximizes the utility of generations instead of maximizing the log-likelihood of preferences, and suggests that the best loss depends on the inductive biases most appropriate for a given setting, an oft-overlooked consideration.
A machine-learning approach called CheMeleon provides a practical way to develop new drugs or other molecules with much less detailed, expensive experimentation.
Research Manager Mike Walker reflects on a career spanning hacker culture, cybersecurity, and AI, sharing lessons about trust, teamwork, leadership, and why solving difficult problems requires curiosity, judgment, agility—and an understanding of the rules. The post Learn the rules: The hacker mindset appeared first on Microsoft Research.
Learn how Google Antigravity and our Cheminformatics Skills accelerate drug discovery workflows, search compounds, and propose novel rigidified macrocycles.
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.