NON-ATHLETIC APPLICATIONS OF CREATINE SUPPLEMENTATION IN WOMEN - A NARRATIVE REVIEW

Abstract

Creatine is one of the most extensively studied dietary supplements and is well known for its role in cellular energy metabolism, muscle function, and exercise performance. However, increasing evidence suggests that its physiological effects may extend beyond athletic applications, particularly in women. This narrative review aimed to summarize and evaluate current evidence regarding the non-athletic health benefits of creatine supplementation in women, with a focus on cognitive function, mood, bone health, reproductive health, and overall metabolic and physiological well-being. A literature search was conducted using PubMed and Google Scholar databases with the keywords “creatine”, “supplementation”, and “women”. English-language studies published from 2015 onward were included, and reference lists of relevant articles were screened to identify additional sources. The available evidence indicates that creatine supplementation may positively influence cognitive performance, brain health, and reproductive physiology, while also supporting healthy aging in women. Potential benefits appear particularly relevant during periods of hormonal transition, such as pregnancy and menopause, when alterations in creatine metabolism may increase physiological demands. In contrast, findings regarding bone health remain inconsistent and require further investigation. Overall, creatine supplementation is considered safe and well tolerated when consumed at recommended dosages. Despite promising findings, the current evidence base remains limited by the relatively small number of female-specific studies and methodological heterogeneity. Further high-quality clinical trials are needed to establish the efficacy, safety, and optimal application of creatine supplementation across different stages of the female lifespan.