It is demonstrated that prenatal alcohol exposure induces profound and persistent histomorphological, cellular, and signaling alterations in the mammary gland in the absence of a carcinogenic challenge or genetically introduced oncogenic driver.
Prenatal exposure to organophosphate pesticides has been increasingly associated with long-term reproductive failure; nevertheless, their effects on uterine developmental programming are still little understood. This study examined whether in utero exposure to acephate causes lasting uterine damage in female rat progen...
M. Jalouli, A. Feriani, W. Aldahmash et al.· Food and Chemical Toxicology· 0 citations
Developmental exposures profoundly shape lifelong health by altering disease resilience later in life. One potential cause of increased disease susceptibility is an altered immune system, originating in epigenetically maladaptive hematopoietic stem cells (HSCs). Here, we establish perinatal nicotine exposure (PNE) as a...
M. Rommel, T. Cool, A. R. Y. Baena et al.· Stem Cell Reports· 0 citations
Previous studies showed that abnormally high glucocorticoid exposure during pregnancy impaired fetal development and health. However, its impacts on fertility in adult male offspring and the underlying mechanisms remain unknown. Here, pregnant mice were treated intragastrically with prednisone (PDN), a widely used synt...
Kai-Wen Wang, Wei-Hsiung Chang, Yong-Wei Xiong et al.· Journal of Hazardous Materia...· 0 citations
This study investigated the effects of subchronic exposure to Voliam Targo® (VT), a binary insecticide containing abamectin and chlorantraniliprole, on maternal reproduction, lactation, lipid metabolism, milk composition, and mammary gland integrity in female rabbits. Thirty nulliparous rabbits (30 females and 30 males...
R. Aroun, N. Z. Daoudi, H. Khaldoun et al.· Reproductive Toxicology· 0 citations
