Anti-Hyperlipidemic Activity of Extract Fractions of Vernonia Calvaona on Fructose and Streptozotocin Induced Diabetic Rats
TL;DR
From the results of this study, it maybe suggested that extract from Vernonia Calvaona may have beneficial effects in the management of dyslipidemia, a complication associated with diabetes mellitus.
Abstract
Diabetes mellitus is a chronic metabolic disorder associated with elevated blood glucose levels with various complications including dyslipidemia. Management of dyslipidemia is an important aspect of diabetes care to prevent cardiovascular complications. Fifty-four rats divided into 9 groups was employed for this study. Diabetes was induced using 10% Fructose/40 mg/kg body weight of streptozotocin. Group 1 and 2 serves as NC and DC and were administered placebo, group 3 administered metformin 500mg/kg bodyweight and group 4-9 received 100, 200 and 400 mg/kg body weight extract of VC respectively. Administration lasted for 21 days and animal were sacrificed and blood collected by cardiac puncture for biochemical analysis. Total cholesterol (TC) concentration did not show significant changes in any of the treatment groups. However, HDL concentration was significantly lower in the diabetic control (DC) group compared to the normal control (NC) group, while the highest dose of Vernonia calvaona extract (EVc 100) showed a significant increase in HDL concentration compared to NC group. Triglyceride (TG) and very low-density lipoprotein (VLDL) concentrations were higher in DC compared to NC, but were significantly reduced in the metformin (MET) and all Vernonia calvaona treatment groups compared to DC. From the results of this study, it maybe suggested that extract from Vernonia Calvaona may have beneficial effects in the management of dyslipidemia, a complication associated with diabetes mellitus.