An optimised serological machine learning model enabling targeted test-and-treat for Plasmodium vivax malaria

Validation of serological markers of recent exposure to Plasmodium vivax in Cambodia: a longitudinal cohort and cross-sectional study

This study provides the first validation of serological markers of P. vivax exposure to detect individuals likely harbouring hypnozoites in rural Cambodia, and compares it with molecular surveillance for identifying at-risk populations in low-transmission settings.

Diagnostics for Hemorrhagic Fever Viruses: Lassa Fever as an Example.

A plasmid-based system that generates LASV RNA controls spanning major viral lineages is established that supports field-oriented detection of genetically diverse LASV and provides a broader approach for diagnostic development for high-consequence RNA viruses.

A machine learning approach for differential classification of chikungunya virus: an explainable AI study based on surveillance data.

Serological differentiation between Mpox infection and vaccine-induced immunity: a mini-review

In recent years, mpox has emerged as a significant global public health threat. The widespread distribution of the virus, coupled with the legacy of historical smallpox vaccination, has underscored the critical need to serologically distinguish between natural mpox infection and vaccine-induced humoral immune responses...

Reverse vaccinology approach for the design of a transmission-blocking vaccine by targeting the malaria vector Anopheles

This multi-epitope malaria TBV demonstrated predicted immunogenic potency without evidence of allergenicity or toxicity, suggesting its potential to limit the transmission of multidrug-resistant Plasmodium strains.

Modelling anti-Ov16 seroprevalence for the control and elimination of onchocerciasis

The World Health Organization aims to verify elimination of onchocerciasis transmission in 12 endemic countries by 2030. Serological assays detecting IgG4 antibodies against the Onchocerca volvulus Ov16 antigen guide decision-making regarding start- and stop-mass ivermectin treatment, post-treatment and post-eliminatio...