Tracing the dynamic recruitment trajectory of Optineurin between the centrosome and other macromolecular assemblies, signifying its role in cell cycle progression
It is reported that OPTN progressively dissociates from centrosomes during mitosis, redistributes to cytokinetic structures, accumulates at the spindle midzone, and then concentrates at the midbody during cytokinesis, establishing a definitive spatiotemporal roadmap that can be strategically utilised to study its functional role in cell division.
Evidence is found that two distinct patterns of force generation complex behavior, microtubule interactions and cortical flows, emerge at the millisecond and second time scales, respectively.
G. A. Edwards, John B. Linehan, A. Maddox et al.· Molecular Biology of the Cel...· 0 citations
Polarization is crucial for the proper functioning of epithelial cells. Early hallmarks include the trafficking and enrichment of polarity molecules to form the apical membrane (AM) or cell–cell junctions, and the apical positioning of the centrosome. However, the dependencies among polarity molecules, AM formation, an...
Po-Kai Wang, Kung-Hui Lin, Tang K. Tang· eLife· 0 citations
RapC is a Rap-subfamily small GTPase in Dictyostelium whose developmental function remains largely uncharacterized. Upon starvation, individual amoebae aggregate and undergo morphogenetic transitions to ultimately produce a fruiting body, a process requiring precise spatiotemporal regulation of a single apical tip as t...
Han Nara, Uri Han, Dahyeon Kim et al.· Cells· 0 citations
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