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Tracing the dynamic recruitment trajectory of Optineurin between the centrosome and other macromolecular assemblies, signifying its role in cell cycle progression

Oct 2026 · bioRxiv · 0 citations · 44 references
Biology

TL;DR

It is reported that OPTN progressively dissociates from centrosomes during mitosis, redistributes to cytokinetic structures, accumulates at the spindle midzone, and then concentrates at the midbody during cytokinesis, establishing a definitive spatiotemporal roadmap that can be strategically utilised to study its functional role in cell division.

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