TL;DR
Docking showed flupyrimin bound NlCYP6FL4 with highest affinity with highest affinity via hydrogen bonds and hydrophobic interactions, which reveals P450 functional differentiation, aiding resistance management.
Substantial resistance to several frequently used insecticides, particularly buprofezin and imidacloprid, is demonstrated, accompanied by enhanced detoxification enzyme activity and altered biological performance within integrated brown planthopper management programmes.
It is demonstrated that metabolic resistance mediates cross-resistance between pyriproxyfen and pyrethroids in Ae.
Findings represent direct evidence of P450-mediated metabolic detoxification of pyridalyl, establishing CYP12A2 as a critical biomarker for field resistance monitoring and a promising target for integrated insecticide resistance management (IRM) strategies.
Assessment of insecticide resistance in D. citri field populations from major citrus-producing provinces across the Guangxi-Hunan-Jiangxi region provided region-specific baseline data to support targeted, population-specific resistance management for D. citri in one of China's most important citrus-producing regions.
The over-expression of CYP6CM1 is associated with resistance to imidacloprid, clothianidin, thiacloprid and thiamethoxam, and Combining molecular techniques with bioassays is useful for identifying biologically relevant levels of resistance.
This study functionally validates that LmCYP99A3 mediates mesosulfuron-methyl resistance in L. multiflorum, expanding the understanding of the metabolic basis of NTSR in this global weed species.
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