TL;DR
The use of lung organoids to investigate age-related lung diseases, including chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis, and integration with multi-omics approaches are highlighted.
F elucidating the interplay between progenitor senescence and respiratory disease pathogenesis not only deepens the mechanistic understanding but also establishes a foundation for developing novel, senescence-targeted therapies that hold promise for clinical translation.
Pulmonary fibrosis is a frequent complication of abnormal tissue repair following lung injury by many causes. It can be found in various diseases and clinical conditions, such as idiopathic pulmonary fibrosis, cancer-treatment-induced lung injury, and other occupational, environmental, and autoimmune lung diseases. Tho...
Alveolar macrophages (AMs), as primary immune sentinels in the respiratory tract, are uniquely adapted to tissue‐specific demands shaped by local factors and the physiological environment, maintaining airway homeostasis through the clearance of surfactants and particulates. While AMs exhibit remarkable plasticity shape...
The core mechanisms of how inter‐organelle network disruptions drive fibrosis are clarified, with the goal of identifying critical organelle nodes to disrupt pathogenic metabolic reprogramming and ultimately provide a rationale for developing new treatments.
Experimental models of renal fibrosis, kidney organoid generation and characterization, organoid-based fibrosis modeling, and future strategies to improve their translational value are summarized.
The maintenance of intestinal epithelial homeostasis and regenerative potential is fundamentally orchestrated by intestinal stem cells (ISCs). Aging is associated with a pronounced decline in intestinal function, with ISC dysfunction emerging as a pivotal determinant of tissue-level senescence. This process does not oc...
We use cookies to run the site and, with your consent, for analytics and to show ads. See our Cookie Policy.
