Mar 2026· Science China Life Sciences· Vol 69, pp. 2700 - 2715· 0 citations· 57 references
Medicine
TL;DR
This hydrogel-based platform integrates multiple bioactive functions, presenting a promising strategy for the clinical management of DFUs, and exhibits pH-responsive behavior, along with potent antioxidant and hypoglycemic effects.
This in situ formed multifunctional hydrogel dressing effectively reduces excessive inflammation, enhances neovascularization, accelerates collagen tissue regeneration, and advances wound healing by improving the pathological microenvironment of diabetes.
Yunshu Yang, Bin Tang, Meng Zhou et al.· Materials Today Bio· 0 citations
The physicochemical properties of chitosan are summarized and the molecular mechanisms underlying hydrogel-mediated diabetic wound repair are systematically examined, including cation-mediated disruption of microbial membranes, Keap1/Nrf2-dependent antioxidant signaling, NF-κB-regulated immunomodulation, and VEGF-drive...
Hong-Yun Chen, Ying Xin, Cheng-Sheng Liu et al.· International Journal of Bio...· 0 citations
A multi-functional dynamically responsive composite hydrogel with high-efficiency antioxidant, antibacterial, and pro-angiogenic capacities was fabricated and synergistically intervenes in multiple pathological links of diabetic wounds, overcomes several key limitations of existing dressings, and provides an innovative...
Yan-Ling Li, Yu-Han Mao, Jie Zhang et al.· Gels· 0 citations
In vitro characterization demonstrated that the GOx@Zn‐MPN hydrogel possesses pH‐responsive release, stable enzymatic activity, and excellent ROS scavenging capacity, and animal experiments confirmed that this hydrogel significantly accelerates the healing of full‐thickness skin defects in diabetic mice.
A composite hydrogel incorporating organic-inorganic peptide-zinc nanoflowers incorporating organic-inorganic peptide-zinc nanoflowers for sustained local delivery regulated the diabetic wound microenvironment through antibacterial, antioxidant, anti-inflammatory, and pro-angiogenic activities, thereby promoting tissue...
Xin Dan, Han Chen, Song-Jie Li et al.· Regenerative Biomaterials· 0 citations
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