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Open access Aug 2026

Transcription-protein dissociation reveals disrupted cellular stress pathways in the prefrontal cortex of depression and schizophrenia subjects

A marked transcription-protein dissociation in key cellular stress pathways in the DLPFC of MDD and SCZ subjects is revealed, supporting multilayer regulation of inflammatory, autophagy-related, and UPR responses in the psychiatric brain.

C. Ulecia-Morón, Á. G. Bris, Lucía Inglada-Pérez et al. · 0 citations
Open access Sep 2026

Integrative Transcriptomic and Network Pharmacology Analysis Reveals Candidate Molecular Associations and Hypothesis-Generating Drug-Gene Relationships in Major Depressive Disorder

The data support exploratory molecular associations involving stress-response and immune/chemokine-related genes but do not establish causal mechanisms, validated biomarkers, or therapeutic efficacy and require covariate-adjusted replication and experimental validation.

Laura Gomes Libório, Sophia Massesine Pimentel, Sara Laíse Cordeiro · 0 citations
Sep 2026

Prevalent and characteristic alterations in blood-brain transcriptomic-functional imaging coupling in schizophrenia.

Findings reveal distinct, reproducible dysregulation of peripheral-central functional coupling in SCZ, offering a multi-scale framework for understanding its pathophysiology and highlighting the potential of trans-scale features as candidate biomarkers for diagnosis and mechanistic insight.

Yu-Sha Ji, Yi-Feng Liu, Zhi-Qiang Mu et al. · 0 citations
Open access Aug 2026

Autism-specific spliceosomal transcriptomic signatures in prefrontal cortex contrasted with bipolar disorder.

These results support transcriptomic divergence in the prefrontal cortex, with ASD characterized by spliceosomal dysregulation, contrasting with metal ion response, vascular regulation and inflammation-associated signals in BD.

Pedro Marmontel, F. D. Rabelo-da-Ponte, F. Kapczinski et al. · 0 citations

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