Aug 2026· Viruses· Vol 18, pp. 909· 0 citations· 89 references
Medicine
TL;DR
This review discusses existing research limitations and proposes future directions including genomic surveillance, reverse genetics verification and broad-spectrum vaccine development to support BCoV prevention and control.
Abstract
Bovine coronavirus (BCoV) is a key pathogen causing calf diarrhea and bovine respiratory diseases, bringing sustained economic losses to the cattle industry. As an RNA virus, BCoV possesses high mutation and recombination capacities, leading to prominent genomic genetic diversity. The genome contains hypervariable and conserved regions, with the S (especially S1), HE and Open Reading Frame (ORF4) genes serving as major variation hotspots linked to viral antigenicity, tissue tropism shift and immune evasion. Host immune pressure drives strong positive selection on S protein antigenic variation. This review discusses existing research limitations and proposes future directions including genomic surveillance, reverse genetics verification and broad-spectrum vaccine development to support BCoV prevention and control.
The results suggest that CRCoV may disseminate beyond the respiratory tract, and established probe-based reverse transcription quantitative polymerase chain reaction (RT-qPCR) and nanoplate-based reverse transcription digital polymerase chain reaction (RT-dPCR) assays as versatile molecular tools for the detection and...
Turkey coronavirus (TCoV) is an enteric gammacoronavirus that has become a re-emerging pathogen of major economic importance in commercial turkey production. First identified in the 1970s, TCoV continues to circulate endemically and periodically resurges as a primary viral contributor to poult enteritis complex (PEC) a...
Biswash Ghimire, Abhijith Anil, Menuka Bhandari et al.· The Veterinary Journal· 0 citations
Highlights • Whole-genome sequencing identified three FCoV viral genomes (FIPV-170, FIPV-193, and FIPV-246) that belong to FCoV type-I.• These FCoV viral genomes shared about 90% nucleotide similarity with FCoV type-I strains and approximately 83% similarity with FCoV type-II strains, indicating substantial genomic dri...
A. Shah, Csaba Vagra, Nadine Moawad et al.· Virus Research· 0 citations
AbstractThe Newcastle disease virus (NDV) is the etiological agent of a highly transmissible avian disease, first recognized in 1926. The virus continues to pose a substantial threat to both commercial and domestic poultry farming globally, causing major outbreaks with high mortality rates and resulting in considerable...
A. D. Solovieva, O. Kondakova, D. Granovskiy et al.· Avian Pathology· 0 citations
This research presents a comprehensive analysis of the genetic landscape of prevalent NDV strains in Bangladesh between 2010 and 2024 using full‐length coding sequences of the fusion (F) gene and unraveled considerable genetic divergence.
Farah Zereen, Md. Abdur Rahman, M. Hossain et al.· Veterinary Medicine Internat...· 0 citations
Substantial genetic variation in the HV region of nsp2 among NA-PRRSV field strains, largely associated with recombination and immune escape is revealed, highlighting epidemiological risks to vaccine efficacy and underscore the need for continuous molecular surveillance to support effective PRRSV control in Vietnam.
T. Le-thi, Van-Anh Huynh-Nguyen, Tram-Anh Bui-Nguyen et al.· Acta Veterinaria Hungarica· 0 citations
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