Aug 2026· Journal of Zhejiang University SCIENCE B· Vol 27, pp. 923 - 926· 0 citations· 16 references
Medicine
TL;DR
Young pigs are more susceptible to PRV and the infection in piglets is nearly 100% fatal, whereas adult pigs exhibit reproductive disorders such as abortion, stillbirths, and reduced fertility, ultimately decreasing farm productivity.
Abstract
Pseudorabies virus (PRV), known as porcine herpesvirus type I, belongs to the α-herpesvirus subfamily of the herpesviridae family. Its virions are oval or round, with a genome of approximately 143 000 bp and a high guanine-cytosine (GC) content of 73% (Pomeranz et al., 2005). While swine are the natural host and the virus has caused significant economic loss to the pig industry, PRV can infect other mammals, causing acute infectious diseases characterized by neurological symptoms (He et al., 2019; Cheng et al., 2020). Young pigs are more susceptible to PRV and the infection in piglets is nearly 100% fatal, whereas adult pigs exhibit reproductive disorders such as abortion, stillbirths, and reduced fertility, ultimately decreasing farm productivity (Zuckermann, 2000). Due to its global impact, PRV is classified as a Class B infectious disease by the World Organization for Animal Health (WOAH).
The triple TaqMan-qPCR method developed in this study can quickly and accurately identify the prevalent PRRSV genotypes in pig populations and provides a reliable technical tool for formulating targeted immunization and prevention strategies.
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A novel assay targeting the variable region of the outer capsid protein gene of the PPV-7 genome demonstrated strong potential for field-based detection of PPV-7 circulating within the swine population of Haryana, India, marking the first report of its kind from this region.
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A one-tube visual detection platform based on recombinase‑aided amplification (RAA) and PfAgo nuclease for simultaneous detection of the highly conserved N gene and the virulence‑associated ORF3 gene of PEDV, offering a powerful tool for on-site clinical diagnosis, strain differentiation, and epidemiological monitoring...
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The observed clinical signs, viral dissemination, and histopathological lesions indicate that HN/ZZ/2025 is capable of causing clinically evident disease in experimentally infected cats, establishing HN/ZZ/2025 as a useful isolate for future studies of FCV genetic diversity and pathogenesis.
Jia-You Xing, Wen-Jie Xu, Zi-Xuan Fu et al.· Microorganisms· 0 citations
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