The results suggest that the anterior cingulate can be a core cortical structure for the bilateral propagation of CM stimulation, and DTI findings indicate that the propagation of CM stimulation may rely upon integrity of structural connections between CM and these key cortical regions.
Overall, the available evidence supports a transition from a predominantly hippocampocentric framework toward a distributed thalamocortical network model of TLE, and emerging longitudinal evidence further suggests that thalamocortical networks may undergo postoperative reorganization following successful epilepsy surge...
G. Bevacqua, Marco Ciavarro, L. Gaetani et al.· Brain Structure and Function· 0 citations
Objective. Temporal lobe epilepsy (TLE) is associated with disrupted functional integrity in the amygdala-hippocampus complex. Cortico-cortical evoked potentials (CCEPs) can characterize this disruption and have been proposed as biomarkers of the epileptogenic zone (EZ), but their study is typically limited by the spat...
O. Feys, M. Josyula, Nilu Sinha et al.· medRxiv· 0 citations
A pragmatic, evidence-informed programming framework for CM-DBS is proposed that emphasizes postoperative contact localization, standardized initial stimulation settings, and stepwise titration of stimulation exposure to enable prospective optimization.
M. AlQahtani, Michal Stern-Zimmer, P. Jain et al.· Epilepsia· 0 citations
Unilateral ANT-DBS was associated with a clinically meaningful reduction in ES in this highly refractory case, suggesting a potential therapeutic role even when bilateral implantation is not feasible.
Takumi Mitsuhashi, Y. Iimura, Hiroharu Suzuki et al.· Epilepsy & Behavior Reports· 0 citations
The multimodal findings suggest that increased hippocampal connectivity in the epileptogenic hemisphere may reflect pathological hypersynchronization that disrupts efficient memory network coordination in TLE and highlight hippocampal connectivity as a promising candidate biomarker for characterizing individual memory...
Ruxue Gong, Xiaolong Peng, Rebecca W. Roth et al.· Epilepsia· 0 citations
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