Integrated proteomic profiling and in silico miRNA and lncRNA analysis of glucose-capped fisetin silver nanoparticle-mediated cell proliferation arrest in breast cancer
GF-Ag NPs can modulate the expression of key genes and signalling pathways involved in breast cancer progression and apoptosis, suggesting that GF-Ag NPs can modulate the expression of key genes and signalling pathways involved in breast cancer progression.
Novel insights are provided into the molecular mechanism underlying ZEA-induced promotion of endometrial cancer, highlighting the potential role of miR-204 as a key mediator and contributing to understanding the role of environmental factors in cancer development.
Varsha Singh, Saria Anjum, Payal Mandal et al.· Toxicology and Applied Pharm...· 0 citations
This study identified five lung cancer-associated hub genes and provided preliminary evidence that resveratrol may modulate their expression, and provides a multi-level molecular framework for further investigation of resveratrol-responsive networks in lung cancer.
Jing-Hua Yang, Han-Xiu Wei, Jie Li et al.· Cell Biochemistry and Biophy...· 0 citations
The integration of multi-omics data revealed the activation of compensatory mechanisms aimed at restoring cellular homeostasis, including metabolic rewiring and stress-response pathways, although these responses were insufficient to counteract nanosystem-induced cytotoxicity.
M. P. Buendia-Nacarino, Dominik Bulfon, Nikola Tom et al.· Pharmaceutics· 1 citation
A multidimensional, integrated analysis model of "components-transcriptome-clinical data" is developed to systematically elucidate the mechanisms underlying TCM prescriptions and indicate that DGSY San inhibits breast cancer proliferation and induces apoptosis through the MAPK pathway.
Jing Wang, Li Zhang, Ying Yu et al.· Current Medicinal Chemistry· 0 citations
Although specific mRNAs serve as key structural hubs, hsa-miR-378c and hsa-miR-449a emerge as robust independent prognostic biomarkers, providing important insights into TNBC risk stratification and potential targeted therapeutic strategies.
Selim Öğüt, Ebru Cingöz Çapan, Günnaz Çapan et al.· Journal of clinical practice...· 0 citations
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