Aug 2026· Nan fang yi ke da xue xue bao = Journal of Southern Medical University· Vol 46 8, pp.
1915-1925
· 0 citations
Medicine
TL;DR
PPT1 overexpression promotes GC progression by activating the ERK signaling pathway and thereby modulating lipid metabolism, suggesting its potential as a novel prognostic biomarker and a therapeutic target for GC.
TGFBR3 interacts with FATP2 and is associated with the regulation of migration and invasion in lung cancer cells, potentially involving the FATP2-ACSL1 axis.
Tian Luo, Yuanyuan Wu, Nuoya Ma et al.· Frontiers in Oncology· 0 citations
Experimental data indicated that P4HA3 facilitated GC cell proliferation, migration and invasion, and enhanced glycolytic activity and increased the expression of key glycolysis-related proteins, suggesting that P4HA3 may induce a broader metabolic activation rather than an exclusively glycolytic shift.
Tao Wang· Pakistan Journal of Pharmace...· 0 citations
The study identifies G6PD as a key metabolic gene linked to tumor progression; this finding not only offers potential insights into the molecular mechanisms of BRCA but also supports further exploration of metabolism-related therapeutic strategies.
Zhun Zhang, Ying Fu, Yu-Song Zhou et al.· Frontiers in Pharmacology· 0 citations
Bioinformatics analyses suggest that EPHX2 may participate in metabolic and tumor progression-related regulatory networks and may serve as a prognostic biomarker in LUAD.
Findings link FSCN1 to the AKT/mTOR/SREBP1/(FASN/SCD1) lipogenic axis and the p38 MAPK/PPARα/ACOX1 peroxisomal FAO pathway, implicating FSCN1 in lipid metabolic regulation and CRC progression, while suggesting a putative functional regulatory axis and a promising candidate therapeutic target for CRC.
HIST1H4L was significantly upregulated in SCLC tumors versus normal tissues and enriched in DNA transcription-related pathways and correlated with poor patient survival; critically, high HIST1H4L expression correlated with poor patient survival.
Shi-Cheng Feng, Min Feng, Zhi-Qiang Lu et al.· Frontiers in Oncology· 0 citations
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