This review will highlight recent metabolomics discoveries on unravelling the complex phytochemical composition of selected medicinal plants in producing neuroprotective bioactive compounds and therapeutic potential to combat neurodegenerative related disease especially Alzheimer’s disease (AD).
The main technical platforms and data analysis workflows of metabolomics are summarized, consolidated diagnostic applications of metabolomics in the fields including malignant tumors, metabolic diseases, neurological disorders, and autoimmune diseases are consolidated, while discussing current bottlenecks in sample sta...
Chun-Lei Xie, Cong-Cong Tang, Qi Tang et al.· Clinical Medicine and Pharma...· 0 citations
Natural products remain significant sources of bioactive compounds for agriculture and medicine, though conventional discovery approaches are constrained by complex biosynthetic pathways, low metabolite yields, rediscovery of known compounds and labour-intensive screening. The combination of multi-omics technologies su...
Akash Kishor Rokade, Ha Nguyen· Vietnam Journal of Biotechno...· 0 citations
Degenerative diseases impose a growing global health burden, whereas currently available therapies remain limited by adverse effects, drug resistance, and variable clinical efficacy. This critical narrative review used a structured, database-informed search of PubMed, Scopus, and ScienceDirect to identify original stud...
Indah Solihah, A. N. Garmana, N. Happyana et al.· Biomedicine & pharmacotherap...· 0 citations
Background: Alzheimer’s disease (AD) is a complex neurodegenerative disorder with a global impact, highlighting an urgent need for effective dietary therapeutic agents for the development of brain-healthy functional foods and medicines. This study focuses on the edible red alga Pterocladiella capillacea from Zhanjiang,...
Mei-Cai Yue, Long-Jian Zhou, Wan-Rong He et al.· Nutrients· 0 citations
These multi-target interactions suggest that S. samarangense phytochemicals can modulate key DR-associated pathways, and exhibits promising multi-target activity against Diabetes retinopathy.
Arun Kandhan, B. Mathew, Sundarrajan Thirugnanasambandam· Frontiers in Bioinformatics· 0 citations
Overall, medicinal mushrooms show potential as multi-target functional foods capable of modulating core pathological networks in T2DM, and will critically depend on rigorous standardization of bioactive preparations, mechanistically driven clinical trials, and systems-level multi-omics integration to establish causal l...
Radoslav Z. Pavlović, J. Novaković, G. Ramenskaya et al.· Frontiers in Nutrition· 0 citations
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