2024 Joint Meeting of EEG and Clinical Neuroscience Society (ECNS), the International Society for Neuroimaging in Psychiatry (ISNIP), the International Society for Brain Electromagnetic Topography (ISBET), and the International Society for Functional Source Imaging (ISFSI)
Abstract
: Over the past decade, the Diagnostic and Statistical Manual ’ s method of prescribing medications based on presenting symptoms has been challenged. The shift toward precision medicine began with the National Institute of Mental Health and culminated with the World Psychiatric Association ’ s posit that a paradigm shift is needed. This study supports that shift by providing evidence explaining the high rate of psychiatric medication failure and suggests a possible fi rst step toward precision medicine. A large psychiatric practice began collecting electro-encephalograms (EEGs) for this study in 2012. The EEGs were analyzed by the same neurophysiologist (Board-certi fi ed in electroencephalography) on 1,233 patients. This study identi-fi ed 4 EEG biomarkers accounting for medication failure in refractory patients: focal slowing, spindling excessive beta, encephalopathy, and isolated epileptiform discharges. Each EEG biomarker