Integrated Phytochemical, Computational and In Vitro Evaluation of the Oocysticidal Activity of Pleurotus ostreatus Extract Against Cryptosporidium parvum
Aug 2026· Cell Biochemistry and Biophysics· Vol 84, pp. 4347 - 4367· 0 citations· 78 references
Medicine
TL;DR
Findings collectively underscored P. ostreatus as a potential natural antiparasitic agent, indicating that its sterol-rich extract may demonstrate oocysticidal activity via multi-target molecular interactions and direct impacts on oocyst integrity.
Overall, compound 2 exhibited the stronger experimentally measured yeast α-glucosidase inhibition, whereas the computational findings provide target-specific hypotheses rather than confirming multitarget antidiabetic activity.
M. C. Nguyen, Minh-Tri Le, Huynh Nguyen Khanh Tran· RSC Advances· 0 citations
The authors' data provided promising drug‐like phytoconstituents in the S. nobilis leaf offering future drug discovery in mental health treatment and supported aniline and isoquinoline as potential candidates requiring further pharmacological validation due to their interactions with chimeric alpha1GABAA receptor prote...
Progga Paramita Paul, Musfiqur Rahman Sakib, P. Kundu et al.· Chemistry and Biodiversity· 0 citations
Findings demonstrate that M. quadrifasciata geopropolis contains bioactive diterpenes and isoflavonoids with significant antifungal activity, highlighting its potential as a source of lead compounds for developing new therapeutic strategies against endemic sporotrichosis.
G. D. dos Santos, M. C. Sampaio, R. D. dos Santos et al.· ACS Omega· 0 citations
Background: Plasmodium falciparum, the most virulent malaria parasite, continues to develop resistance to available drugs. Mitragyna inermis (Rubiaceae) is traditionally used in Africa for the treatment of malaria and has shown antiplasmodial activity against P. falciparum. Previous studies on this plant and related sp...
Adelphe Dounia, J. Nyemb, Roméo Toko Feunaing et al.· Scientia Pharmaceutica· 0 citations
Findings indicate that the tested compounds possess potential as antibacterial and quorum sensing inhibitory agents by targeting LuxR, however, further in vitro and in vivostudies are required to validate their biological activity and therapeutic potential.
Ziyan Iswahyudi, M. Fadjar, Y. Maimunah et al.· Journal of aquaculture and f...· 0 citations
This study investigated the phytochemical composition and antibacterial activity of Zingiber officinale rhizome extracts obtained using solvents of different polarities (methanol, ethyl acetate, chloroform, dichloromethane, and n-hexane). GC-MS identified 65 volatile and semi-volatile compounds across the five solvent...
Hải Anh Trần, V. N. Le, T. Q. Bui et al.· Current Research Bulletin· 0 citations
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