Antimicrobial efficacy of intracanal medicaments targeting E. faecalis biofilm: An in vitro study

Abstract

Enteroacoccus faecalis biofilms are a major cause of persistent endodontic infections and treatment failure. Therefore, it is of interest to evaluate and compare the antimicrobial efficacy of triple antibiotic paste, simvastatin, propolis and chitosan against E. faecalis biofilms in extracted human teeth. Antimicrobial activity was assessed by colony-forming unit counts at the apical and middle thirds following medicament application. Chitosan showed the lowest bacterial counts and significantly greater antimicrobial efficacy than the other tested intracanal medicaments. Thus, data show chitosan as a promising biocompatible anti-biofilm agent for intracanal disinfection.