[Combined detection of urinary-related protein and fecal calprotectin for early warning of IgA vasculitis with nephritis in children].

Diagnostic value of serum uric acid, CIAS1 and CD354 in chronic glomerulonephritis

The serum uric acid, CIAS1 and TREM-1 levels were elevated in patients with CGN and closely related to the stage of CGN, and the combination of these three indicators had relatively high diagnostic value for CGN.

Urinary Biomarker Analysis of the SANCTUARY Trial: Insights into IgA Nephropathy Pathophysiology and Ravulizumab Mechanism of Action.

BACKGROUND Complement activation in IgA nephropathy (IgAN) drives inflammation, nephron loss, and progressive kidney damage. We evaluated urinary biomarkers among participants with IgAN treated with ravulizumab (terminal complement C5 inhibitor) versus placebo in the Phase 2 SANCTUARY trial and healthy donors. METHOD...

Diagnostic Performance of Serum Leucine-Rich Alpha-2-Glycoprotein 1 and Plasma Calprotectin in Adults with Suspected Acute Appendicitis: A Cross-Sectional Observational Study

Background/Objectives: This study evaluated the diagnostic performance of serum leucine-rich alpha-2-glycoprotein 1 (LRG1) and plasma calprotectin in adults with suspected acute appendicitis, compared them with routine inflammatory markers and clinical scores, and examined their association with abdominal guarding and...

Panel of serum biomarkers for non-invasive assessment of glomerular and tubular injury in patients with chronic glomerulonephritis with and without arterial hypertension

Aim: to analyze histological kidney features in patients with chronic glomerulonephritis (CGN) with and without arterial hypertension (AH) and to assess the relationship between serum cystatin C, neutrophil gelatinase-associated lipocalin (NGAL), and interleukin-18 (IL-18) levels and histological signs of glomerular an...

[Pathological characteristics, therapeutic strategies, and prognostic assessment in children with crescentic IgA vasculitis with nephritis].

Cystatin C, Neutrophil Gelatinase-associated Lipocalin, and Pro-atrial Natriuretic Peptide as Biomarkers in the Assessment of Diabetic Nephropathy Patients.

BACKGROUND Diabetic nephropathy (DN) is a significant microvascular complication linked with diabetes mellitus which leads to chronic kidney disease worldwide. Conventional biomarkers, namely, serum creatinine and albuminuria often fail to detect early renal impairment. AIM The study aimed to compare the utility of s...