Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement and heterogeneous clinical manifestations. Aberrant B-cell activation and elevated levels of B-lymphocyte stimulator (BLyS) play a central role in its pathogenesis [1]. Several B-cell–targeted biologic agents hav...
Bing-Bing Deng, Zhi-Hang Xiao, Hong-Ru Wang et al.· Egyptian Rheumatology and Re...· 0 citations
Objective To evaluate the cutaneous efficacy and glucocorticoid-sparing effects of anifrolumab in systemic lupus erythematosus (SLE) and to assess composite disease activity and flare-related and safety outcomes. Methods PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched through...
Jia-Ni Wang, Fei Liu, Q. Lou et al.· Frontiers in Immunology· 0 citations
Background Telitacicept is a TACI-Fc fusion protein that targets both B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). Evidence in adults with systemic lupus erythematosus (SLE) includes placebo-controlled randomized trials, other comparative studies, and single-arm cohorts. Objectives To as...
Zi-Hua Wang, Huan Li, Ji-Gao Li et al.· Frontiers in Medicine· 0 citations
Relapsing and refractory lupus nephritis (LN) remains difficult to manage despite advances in immunosuppressive and targeted therapies. Rituximab (RTX) is often used as rescue or add‐on therapy, but renal outcomes in this specific setting have not been quantitatively synthesized. PubMed, Embase, and Web of Science were...
Xiao-Long Wang, Shuang Liang, Xiao-Wei Sun et al.· Clinical and Translational S...· 0 citations
IVIG was associated with improvements in several clinical outcomes, particularly in observational studies, including skin fibrosis, gastrointestinal manifestations, and inflammatory myopathies, and the available evidence suggests a potential adjunctive role for IVIG in selected patients.
J. D. de Carvalho, R. P. D. de Araújo, M. G. Danieli et al.· Frontiers in Immunology· 0 citations
Complement inhibitors show promising but heterogeneous signals across individual trials, but marked differences in molecular targets, trial design, and eligibility preclude any inference of a uniform class effect, and underscore the need for mechanism-specific phase III programmes with hard renal endpoints and individu...
Xin-Yu Li, C. Zhong, Li-Nan Zhang et al.· Frontiers in Medicine· 0 citations
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