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Review Open access Oct 2026

Comparative efficacy and safety of B-cell-targeted biologics in systemic lupus erythematosus: a systematic review and network meta-analysis

Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by multisystem involvement and heterogeneous clinical manifestations. Aberrant B-cell activation and elevated levels of B-lymphocyte stimulator (BLyS) play a central role in its pathogenesis [1]. Several B-cell–targeted biologic agents hav...

Bing-Bing Deng, Zhi-Hang Xiao, Hong-Ru Wang et al. · 0 citations
Meta-analysis Open access Sep 2026

Cutaneous efficacy and glucocorticoid-sparing effects of anifrolumab in systemic lupus erythematosus: a systematic review and meta-analysis of randomized controlled trials

Objective To evaluate the cutaneous efficacy and glucocorticoid-sparing effects of anifrolumab in systemic lupus erythematosus (SLE) and to assess composite disease activity and flare-related and safety outcomes. Methods PubMed, Embase, Web of Science, the Cochrane Library, and ClinicalTrials.gov were searched through...

Jia-Ni Wang, Fei Liu, Q. Lou et al. · 0 citations
Review Open access Sep 2026

Efficacy and safety of telitacicept in adults with systemic lupus erythematosus: a systematic review and stratified meta-analysis

Background Telitacicept is a TACI-Fc fusion protein that targets both B-cell activating factor (BAFF) and a proliferation-inducing ligand (APRIL). Evidence in adults with systemic lupus erythematosus (SLE) includes placebo-controlled randomized trials, other comparative studies, and single-arm cohorts. Objectives To as...

Zi-Hua Wang, Huan Li, Ji-Gao Li et al. · 0 citations
Meta-analysis Open access Sep 2026

Rituximab as Rescue or Add‐On Therapy for Relapsing or Refractory Lupus Nephritis: A Systematic Review and Meta‐Analysis

Relapsing and refractory lupus nephritis (LN) remains difficult to manage despite advances in immunosuppressive and targeted therapies. Rituximab (RTX) is often used as rescue or add‐on therapy, but renal outcomes in this specific setting have not been quantitatively synthesized. PubMed, Embase, and Web of Science were...

Xiao-Long Wang, Shuang Liang, Xiao-Wei Sun et al. · 0 citations
Meta-analysis Open access Oct 2026

Efficacy and safety of intravenous immunoglobulin in systemic sclerosis: a systematic review and meta-analysis

IVIG was associated with improvements in several clinical outcomes, particularly in observational studies, including skin fibrosis, gastrointestinal manifestations, and inflammatory myopathies, and the available evidence suggests a potential adjunctive role for IVIG in selected patients.

J. D. de Carvalho, R. P. D. de Araújo, M. G. Danieli et al. · 0 citations
#data science Review Open access Oct 2026

Mapping the complement-targeted landscape in igA nephropathy: a systematic review with structured descriptive synthesis

Complement inhibitors show promising but heterogeneous signals across individual trials, but marked differences in molecular targets, trial design, and eligibility preclude any inference of a uniform class effect, and underscore the need for mechanism-specific phase III programmes with hard renal endpoints and individu...

Xin-Yu Li, C. Zhong, Li-Nan Zhang et al. · 0 citations

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