Spontaneous eye behavior is an objective marker of parkinsonian severity

A principled approach to mouse motor behavior analysis in Parkinson’s disease models

Saccadic network dysfunction underlies eye-movement variability in early Parkinson’s disease

Parkinson’s disease is a neurodegenerative disorder characterized by altered subcortical-cortical connectivity, leading to motor and cognitive deficits. Saccadic eye movement abnormalities are among the earliest and most persistent markers of the disease, serving as sensitive indicators of disrupted oculomotor and cogn...

Impaired olfaction and Parkinsonism: A “hidden gem” in the neurological literature

Clinical observations have supplemented findings by Braak and colleagues demonstrating that, like impaired sense of smell, olfactory bulb involvement by Lewy pathology is a common early feature in Parkinson disease.

Video-based quantification of leg agility in Parkinson’s disease and its relationship to upper extremity motor impairments

Bradykinesia is a hallmark sign of Parkinson’s disease (PD). Current clinical assessment is susceptible to inter-rater variability and only provides a single, ordinal severity score. Here, we propose a computer vision-based framework to quantify distinct motor characteristics from video recordings of the leg agility...

Aberrant Gamma Oscillations in Parkinson's Disease.

Current clinical and preclinical evidence of aberrant gamma oscillations in PD is summarized, underlying mechanisms including parvalbumin interneuron dysfunction, basal ganglia circuit imbalance, and impaired neurovascular coupling are discussed, and how current therapeutic approaches for PD modulate gamma activity and...

An examination of the effect of dual task on gait in Parkinson's disease and REM sleep behavior disorder.

BACKGROUND Gait variability is a hallmark of Parkinson's disease (PD) and has been linked to cognitive deficits and fall risk. Rapid eye movement sleep behavior disorder (RBD) is a strong predictor of synucleinopathies, yet evidence for gait changes in RBD is inconsistent. Performing a dual task increases gait variabil...