TL;DR
The axial/rest tremor ratio, derived from routine MDS-UPDRS part III examination, may serve as a simple and clinically accessible adjunctive marker for distinguishing PSP from PD.
A simple visual comparison of tremor amplitude during spiral drawing versus at rest required no specialized equipment and showed high reproducibility in blinded ratings, and may serve as a practical bedside adjunct for distinguishing DT from Parkinson's disease.
It is suggested that motor subtype-associated differences in cerebellar involvement do not substantially influence ICD symptoms in early PD.
Abstract Progressive supranuclear palsy is a rare and rapidly progressive neurodegenerative syndrome. Clinical manifestations are heterogeneous and include Parkinsonism, postural instability, oculomotor dysfunction and cognitive impairment, with 80% of patients progressing to dementia within 3 years. Cognitive impairme...
Compared to PD, PSP demonstrates a more severe neuropsychological profile marked by frontal and visuospatial deficits, which can improve diagnostic accuracy, early intervention, and differential diagnosis across diverse populations.
Background Parkinson’s disease motor subtypes, tremor-dominant (TD) and postural instability/gait difficulty (PIGD), differ in disease trajectory and prognosis, yet their classification depends on MDS-UPDRS-based clinical ratings that are susceptible to inter-rater variability and medication state. Purpose This explora...
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