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A tumor-specific RANP for precision molecular imaging that activates its radioafterglow signal specifically in the presence of hydrogen peroxide, a key biomarker of the tumor microenvironment is developed.
Sonoafterglow imaging is a promising deep-tissue molecular imaging modality that effectively suppresses autofluorescence and offers enhanced tissue penetration depth compared to conventional optical methods. However, its potential is constrained by the lack of unimolecular, self-sustaining sonoafterglow luminophores. H...
Radio imaging and optical imaging offer complementary advantages for biomedical diagnosis. However, the photosensitizers used in imaging must be degraded to reduce phototoxicity during phototherapy. Herein, we report a novel dicyanomethylene-based near-infrared photosensitizer (PS) that self-degrades via multiple pathw...
Afterglow luminescence imaging offers high sensitivity, deep-tissue readability, and persistent emission for image-guided surgery, but most current probes still require external energy activation, limiting autonomous lesion reporting and increasing the risk of off-target tissue exposure. Here, we report a single-module...
This work delivers a robust molecular design paradigm for non-radiative decay optimization, and for the first time establishes 1700 nm-excitable PAI nano-agents, paving the way for tissue high-quality biomedical imaging.
Ultrabright fluorophores emitting in the second near-infrared (NIR-II, 1000–1700 nm) window are highly desirable for biomedical and optoelectronic applications but remain rare, because fluorescence brightness requires the simultaneous realization of a large absorption coefficient (ε) and a high photoluminescence quantu...
An activatable phototheranostic nanoplatform with turn-on fluorescence and photodynamic immunostimulatory activity that effectively induced immunogenic cell death, thereby boosting the efficacy of photodynamic-immunotherapy and achieving robust suppression of both primary and residual tumors is designed.
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