Oct 2026· Natural Product Research· pp.
1-12
· 0 citations· 33 references
Medicine
TL;DR
B. virgata exhibits multifunctional bioactivities, likely attributed to its alkaloid constituents, supporting its potential as a source of novel therapeutic agents, supporting its potential as a source of novel therapeutic agents.
Abstract
This study aimed to profiling B. virgata leaves extract, evaluate biological activities, and investigate alkaloid interactions targeting EGFR. Extraction was performed using reflux with solvents of increasing polarity, yielding n-hexane, ethyl acetate, and ethanol extracts. Antioxidant activity was assessed using DPPH, CUPRAC, and FRAP assays, while α-glucosidase inhibition was evaluated in vitro. Cytotoxicity was tested against NSCLC cell lines harbouring EGFR L858R/T790M mutations and wild-type. Ethanol extracts showed the highest antioxidant activity (DPPH: 118.95 ± 0.21; FRAP: 9.50 ± 0.29; CUPRAC: 226.84 ± 2.33 TEAC/g extract), strong α-glucosidase inhibition (IC50 = 13.38 ± 0.26 µg/mL), and selective cytotoxicity against H1975 cells (IC50 = 7.19 × 10-14). Alkaloid compounds 1 and 2 interact with key residues, particularly Cys797, with binding affinities of -7.1 and -6.8 kcal/mol, comparable to references. B. virgata exhibits multifunctional bioactivities, likely attributed to its alkaloid constituents, supporting its potential as a source of novel therapeutic agents.
BACKGROUND
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BACKGROUND
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