Assessment of biological potency of 2-(cyclohexyloxy)acetohydrazide based diorganotin(IV) complexes: synthesis, spectral characterization, crystallographic and computational studies
Sep 2026· Research on chemical intermediates (Print)· Vol 52, pp. 7721 - 7744· 0 citations· 60 references
TL;DR
DFT calculations were performed for ligand 2 and its diorganotin(IV) complexes (7–9), providing insights into structural, electronic features of the compounds and also helps to assess various descriptors that help to determine their stability and reactivity order.
Promising compounds like SBB-2, SBB-3, SBB-5, SBB-6, and SBB-7 exhibit favourable physicochemical properties, high drug-likeness, solubility, and a non-toxic profile, making them strong candidates for further development of a promising drug.
D. Upadhyay, Drashti Thanki, C. Somaiya· Current Organic Synthesis· 0 citations
Two novel Ni(II) and Cu(II) mixed-ligand complexes, NiMBIM and CuMBIM, were successfully synthesized using 1-isopropyl-1H-benzimidazole-2-carbaldehyde (MB) and 2-(4,5-diphenyl-1H-imidazol-2-yl)phenol (IM). Their structures were characterized via CHN elemental analysis, UV–Vis and FT-IR spectroscopy, mass spectrometry,...
Abdulaziz M. Almohyawi, A. Abdou, M. Al-Rooqi et al.· Scientific Reports· 0 citations
4-Aminoantipyrine (4-AAP) derivatives are of significant interest in medicinal chemistry because of their diverse therapeutic potentials. In this study, we report the synthesis of five novel 4-aminoantipyrine derivatives (
P1–P5
). The synthetic approach involved the initial preparation of enaminone (
I1
) via a...
I. Filali· Arabian Journal of Chemistry· 0 citations
The results of in vitro and in silico assays discovered the capabilities of the synthesized compounds with promising pharmacokinetic and drug-like properties as active antibacterial drugs.
This study reports the synthesis of a series of oxazepine derivatives via a condensation reaction
between amines and various benzaldehyde derivatives, using benzene as the solvent. The resulting
intermediates were subsequently reacted with pyridine-5,7-dione anhydride in dry benzene to afford oxazepine
derivatives (H1–...
R. Muslim, A. Shallal, M. A. Guma et al.· Chemical Problems· 0 citations
The determined biological activities of Schiff base derivatives obtained from 4-aminoantipyrine via condensation with various aromatic and heteroaromatic aldehydes support these derivatives as promising multifunctional scaffolds for the development of novel antibacterial and anticancer agents.
M. I. Sultan, Muthanna C. Urabee, A. Sadiq et al.· Journal of Genetic Engineeri...· 0 citations
We use cookies to run the site and, with your consent, for analytics and to show ads.
See our Cookie Policy.