Menstrual cycle disorders in adolescent girls after COVID-19

Abstract

Objective: to assess the frequency and pattern of menstrual function disorders in adolescent girls after COVID-19, as well as their association with markers of systemic inflammatory response. Methods: a single-center retrospective observational study was conducted. The study included 103 adolescent girls from menarche to 17 years 11 months 29 days with PCR-confirmed COVID-19 who were hospitalized in 2022—2024. A comparative analysis of interleukin-6, C-reactive protein, D-dimer, and procalcitonin levels was performed depending on the presence of menstrual cycle disorders. Conclusions: a substantial proportion of adolescent girls develop menstrual function disorders in the long-term period after COVID-19. In patients with such disorders, a more pronounced systemic inflammatory response was observed during the acute phase of infection. These findings support the role of inflammatory mechanisms in the pathogenesis of post-COVID menstrual disorders and highlight the need for clinical and laboratory follow-up of adolescents after coronavirus infection.