Evaluation of Antifungal Activity of Chromenoquinoline Derivatives Synthesized in the Medium Temperature Water Using Isinglass–Bassorin Cryogel as a Sustainable Catalyst

Abstract

Our team subscribes to using contemporary, ecologically sound, and sustainable catalysts to produce a range of chromenoquinolines. This was accomplished utilizing the environmentally friendly heterogeneous catalyst isinglass‐bassorin (IG‐BR) cryogel in aqueous media at room temperature in a one‐pot three‐component reaction involving 4‐hydroxycoumarin, aromatic aldehydes, and 3,4‐(methylenedioxy)aniline. The two main significant advantages of this innovative and practical method are the use of water as an ecologically friendly medium and the IG‐BR cryogel as a strong and recyclable heterogeneous catalyst (for at least 4 cycles) that conforms with green chemistry principles to produce target compounds in a brief reaction time (4–5 h) and high product yields (89%–93%). Additionally, all target compounds demonstrated superior inhibition zones at doses of 50 and 75 μg/mL when tested for antifungal activity in vitro against three types of fungal pathogens in comparison with two common antifungal medications.