Efficacy and safety of live combined Bacillus subtilis and Enterococcus faecium in patients with Helicobacter pylori infection: A meta-analysis of randomized controlled trials

Abstract

Highlights • A meta-analysis with 26 randomized controlled trials containing 3,536 patients.• LCBE supplementation increases Helicobacter pylori eradication rate.• LCBE supplementation reduces total and gastrointestinal adverse events.• LCBE supplementation increases Immunoglobulin (Ig)A and IgG levels.• LCBE supplementation reduces tumor necrosis factor-α and interleukin-6 levels.