Mechanisms of Immune Cell Dysregulation in Pancreatic Ductal Adenocarcinoma

Abstract

Simple Summary Pancreatic cancer is an aggressive disease and a leading cause of cancer-related deaths. Cells are able to undergo changes in the tumor, which is correlated with reduced efficacy of the immune system to target and destroy the tumor. This is a leading factor contributing to the severity of the cancer and requires further study. By understanding these factors, potential new treatment outcomes incorporating the immune system may be discovered. This review summarizes the currently known relationship between pancreatic cancer and the immune system.