mir-199b-5p as a potential biomarker of bone fragility in type 2 diabetes mellitus – Dual role in musculoskeletal pathophysiology

04005 Serum Cathepsin - K as Potential Biomarker in Pre and Postmenopausal Osteoporosis Interaction with Diabetes Mellitus and Metabolic Correlates.

Association of CHI3L1 with bone turnover markers in Iraqi postmenopausal women with osteopenia and osteoporosis

Introduction Chitinase-3-like protein 1 (CHI3L1) has been implicated in bone remodeling, but its relationship with bone turnover markers across different degrees of postmenopausal bone loss remains unclear. This study evaluated CHI3L1 together with CTX-1, NTX-1, and osteonectin (OSN) in Iraqi postmenopausal women with...

Differential Expression of miR-146a, IL-31, and IL-33 in Osteoporosis and their Associations with Disease Severity.

INTRODUCTION Osteoporosis is a metabolic disorder characterized by reduced bone mass and microarchitectural deterioration, and it is closely associated with inflammatory processes. This study investigated the expression of microRNA-146a (miR-146a), interleukin-31 (IL-31), and interleukin-33 (IL-33) in osteoporosis and...

Assessment of P1NP and β-CTX in Type 2 Diabetes Mellitus: a Case-Control Study from North India.

Background Type 2 diabetes mellitus (T2DM) is associated with increased skeletal fragility despite normal or elevated bone mineral density (BMD), suggesting impaired bone quality and remodeling. Bone turnover markers (BTMs), including procollagen type I N-terminal propeptide (P1NP) and β-C-terminal telopeptide of type...

Serum Cathepsin-K as Potential Biomarker in Pre and Postmenopausal Osteoporosis Interaction with Diabetes Mellitus and Metabolic Correlates

Osteoporosis is a disease of the skeletal system that results from a decrease in bone density and quality, which weakens bones and causes fragility fractures. The objectives of the study are to estimate the level of serum cathepsin K in pre- and post-menopausal women with osteoporosis compared with DM. A total of 100 w...

The FGF23/α-Klotho Axis in Postmenopausal Osteoporosis: Associations with Bone Mineral Density and Diagnostic Discrimination

Background: Fibroblast growth factor 23 (FGF23) and α-Klotho are key regulators of mineral metabolism and bone homeostasis; however, their combined diagnostic value in postmenopausal osteoporosis remains incompletely understood. This study investigated the associations of serum FGF23, α-Klotho, and the FGF23/α-Klotho r...