2. Swine Genetics in the Era of Complete Genomes and Pangenomes.

Abstract

Recent advances in long read sequencing technologies have promised to overcome the many limitations associated with a single linear incomplete reference genome, including missing sequences, reference bias, and inability to resolve structural variants. An increasing number of telomere-to-telomere (T2T) complete genomes, including haplotype resolved ones, have been or are being generated for several pig breeds. In addition, long read sequencing enabled the production of many highly contiguous pig genome assemblies, forming the basis for swine pangenomes. I will provide an update on projects producing swine complete genomes and pangenomes and discuss how the applications of them will transform swine genetics research and development.