Biochemical Study of CYP1A1 Gene in Non-hodgkin Lymphoma Patients Infection with Epstein Barr Virus

Abstract

Background: The objective of this study was to establish the correlation between genetic variations of the CYP1A1 gene and the proportion of epstein-barr virus (EBV) in individuals diagnosed with non-hodgkin’s lymphoma. Methods: For this case-control study, 75 NHL patients were included together with 50 healthy controls selected from both general hospitals and several private clinical facilities in the Middle Euphrates region of Iraq. The study population spanned from 20 to 69 years of age. Collection of specimens was place between March 2023 and October 2023. CYP1A1 gene polymorphism by sequencing as well as conventional PCR was chosen for the detection of EBV. Result: The results showed that CYP1A1 gene polymorphism distribution was according to GA; GG and AA were 38.7%; 34.7% and 26.6%, In those diagnosed with NHL, the percentages were 28%, 46% and 26% correspondingly. correspondingly in the AHC group. Among patients with NHL, the prevalence of EBV was 21.3% (16 out of 75 cases).