Nanostructured organic interfaces for intravascular bioelectronics

Abstract

Brain–machine interfaces (BMIs) require seamless, long-term integration between electronic materials and biological tissues. This presentation introduces a new class of intravascular neural interface devices that leverage nanostructured organic hybrid materials to achieve high-fidelity brain sensing with minimal invasiveness. We developed ultrathin, stretchable electrodes using antithrombogenic polymers engineered with a hydrated nanointerfacial layer. This bio-inspired design ensures exceptional hemocompatibility and electrical stability under dynamic blood flow. Our hybrid architecture allows for safe deployment within the cerebral vasculature, enabling stable cortical EEG recording for up to 49 days—a performance comparable to conventional subdural electrodes. We will discuss the design principles of these nano-engineered organic materials and their future prospects for next-generation, nanotechnology-driven clinical applications.