Traditional Chinese Herbal Formula YA3D3 Ameliorates Alzheimer's Disease-Like Pathology and Cognitive Impairment in APP/PS1 Transgenic Mice.

Bushen-Yizhi formula promotes neurogenesis and ameliorates cognitive impairment by activating ST8Sia Ⅱ/Ⅳ-PSA-NCAM pathway in ibotenic acid induced mice.

ETHNOPHARMACOLOGICAL RELEVANCE Bushen-Yizhi formula (BSYZ), a traditional Chinese herbal prescription, has been widely used to treat kidney deficiency syndrome and alleviate cognitive impairment associated with Alzheimer's disease (AD). Loss of polysialylation of the neural cell adhesion molecule (PSA-NCAM) is closely...

Shenghui Decoction ameliorates cognitive impairment and neuroinflammation in APP/PS1 mice via modulation of the HMGB1/TLR4/NLRP3 pathway.

ETHNOPHARMACOLOGICAL RELEVANCE Shenghui Decoction (SHD), a traditional Chinese medicinal formula, has previously been reported to alleviate neuroinflammation and improve the cognitive deficits associated with Alzheimer's disease (AD). However, the molecular mechanisms responsible for these protective effects remain inc...

Du-Shu-Wan alleviates Tau protein phosphorylation in Alzheimer's disease by regulating MAPK/JNK signaling pathway.

ETHNOPHARMACOLOGICAL RELEVANCE Alzheimer's disease (AD) is one of the leading causes of cognitive impairment and dementia among the elderly and has become an urgent public health challenge due to population ageing. Du-Shu-Wan (DSW) is an ancient Chinese herbal medicine that aims to enhance memory and soothe the spirit,...

Astragalus polysaccharide alleviates neuropathology and cognitive deficits by modulating gut microbiota and neuroinflammation in an Alzheimer’s disease model

Findings demonstrate that APS alleviates cognitive deficits and AD-like pathology, partially through remodeling gut microbiota and modulating the gut-brain axis, and represents a promising natural compound-based therapeutic candidate for managing cognitive decline associated with Alzheimer’s disease.

LC-MS-based metabolomics reveals the In Vivo effects of cognitive formula 1 in rats with Aβ-induced Alzheimer’s disease

Results indicated that synergistic interactions among multiple CF1 components influence host metabolic pathways, in particular those involved in glycerophospholipid and amino acid metabolism, thereby suggesting an explanation for the alleviation of systemic metabolic dysregulation by the formulation.

miR-584-5p suppresses Aβ1-42-induced apoptosis in Alzheimer's disease cell model via targeting of HDAC1.