Collagen Prolyl 4-Hydroxylase: An Emerging Key Player in Cardiac Fibrosis

The Role of Thrombospondin-2 in Myocardial Fibrosis

This review summarizes the regulatory roles of TSP-2 in myocardial fibrosis under various cardiac disease conditions and discusses its potential molecular mechanisms, and highlights the potential of TSP-2 as a therapeutic target.

Cardiac fibrosis: mechanistic insights and translational advances

The context-dependent role of sirtuin 3 (SIRT3), a mitochondrial nicotinamide adenine dinucleotide (NAD⁺)-dependent deacetylase, in linking mitochondrial homeostasis, oxidative stress, metabolic adaptation, and profibrotic signaling is discussed.

Potential role of CTHRC1 in renal fibrosis

Renal fibrosis is a major morphological feature of chronic kidney disease and is considered an important pathogenetic process that leads to a decline in renal function in the progressive course of the disease. It is characterized by excessive accumulation of extracellular matrix, tubular atrophy, interstitial inflammat...

Current Perspectives on the Role of Collagen Peptide Fragments in Health and Disease

Collagen is the most abundant protein in the human body and a vital component of the extracellular matrix (ECM), where it maintains structural architecture, strength, and mechanical stability throughout the body. Collagen undergoes continuous turnover and remodeling mediated by matrix metalloproteinases (MMPs) and othe...

Platelet GPVI drives fibrotic lung remodeling.

Platelets are a major reservoir of bioactive mediators, including growth factors such as transforming growth factor β1 (TGF-β1), that regulate vascular repair and tissue remodeling. Beyond these classical functions, platelets also participate in inflammatory hemostasis through activation pathways that differ from those...

LOXL4: a key regulatory factor at the intersection of fibrosis and tumor progression