Open access
Clinical Characteristics of People With Extrapulmonary and Disseminated Tuberculosis: A 23-Year Retrospective Cohort Study in People Without HIV Without Pharmacological Immunosuppression
Brenda Aceves-Sánchez
S. Rajme-López
B. Martínez-Guerra
H. Rivera-Villegas
C. Román-Montes
K. Tamez-Torres
L. González-Vázquez
Sebastián Guadarrama-Torres
Oswaldo Lazcano-Delgadillo
Rafael Nares-López
Zurisadai Segura-Ortíz
Karen M. Tepo-Ponce
M. González-Lara
B. Chávez-Mazari
M. Bobadilla-del-Valle
J. Sifuentes-Osornio
A. Ponce-de-León
Medicine
Abstract
Abstract In this retrospective cohort of non-HIV patients without pharmacological immunosuppression, who presented with extrapulmonary/disseminated tuberculosis, the gastrointestinal tract, lymph nodes, and genitourinary tract were the most commonly affected organs. 24-month all-cause mortality was 18%. Cardiovascular disease, central nervous system involvement, mycobacteremia, and ICU admission were independently associated with death.