Exercise-Mediated Regulation of Ferroptosis in Diabetic Cardiomyopathy: Mechanisms and Therapeutic Perspectives

Abstract

Exercise is an important non-pharmacological intervention for the prevention and management of diabetes and its cardiovascular complications; however, the underlying mechanisms by which exercise confers cardiometabolic protection remain incompletely understood. Diabetic cardiomyopathy (DCM) is a major cardiovascular complication of diabetes, characterized by progressive myocardial structural and functional abnormalities associated with oxidative stress, dysregulated lipid metabolism, chronic inflammation, and mi