Circular RNAs orchestrate molecular networks in osteoarthritis: From miRNA sponging to epigenetic and exosome-mediated regulation

Circular RNAs and SIRT1 in post-transcriptional regulation and human disease.

The circRNA-SIRT1 network is proposed as a context-dependent post-transcriptional regulatory network linking non-coding RNA (ncRNA) biology to immunometabolic and stress-response pathways and emphasized as a promising platform for precision diagnostics and disease-specific therapeutic interventions.

Circular RNAs at the crossroads of oxidative stress: novel targets for precision therapeutics

Non-Coding RNA Networks in Systemic Sclerosis: Roles in Pathogenesis, Biomarkers, and Therapeutic Opportunities

A focused narrative review examines microRNAs involved in SSc fibrosis, vasculopathy, and immune dysregulation; extracellular-particle-associated microRNAs; and circulating and hair-derived microRNAs as candidate biomarkers; and summarizes evidence on long non-coding RNAs (lncRNAs), circular RNAs, circular RNAs, yRNAs,...

MicroRNA-phytochemical interactome targeting thioredoxin-interacting protein: a narrative review at the nexus of RNA therapeutics, cancer biology, and metabolic regulation

This narrative review discussed emerging trends on phytochemical-mediated regulation of TXNIP-associated miRNAs, including miR-148b, miR-33a/b, miR-17-5p, miR-224, and miR-20a, with particular emphasis on the conserved miRNA seed region as the principal determinant of target recognition.

Comprehensive landscape and future perspectives of exosomal circular RNAs in cardiovascular disease

This review summarizes the latest investigation on the hyperlink between CVDs and exosomal circRNA, which has far-reaching value for the prevention, early diagnosis, and effective treatment of cardiovascular disorders.

MircoRNAs as regulators of regulated cell death in cancer progression: a focus on ferroptosis, anoikis and pyroptosis

Cancer progression is shaped not only by genetic alterations but also by dynamic remodeling of regulated cell death. MicroRNAs (miRNAs) have emerged as central regulators of these processes by coordinating gene expression, metabolic balance, and stress responses. This review summarizes current understanding of how miRN...